Search results for " conjugates"
Article
Tackling Analytical Method Development for ADCs
Feb 01, 2015
By Cynthia Challener, PhD
BioPharm International
Volume 28, Issue 2
The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …
Article
ADC Development Robust Despite Lackluster Performance
Zulueta, “Antibody Drug Conjugates Against Tumor Stroma: The Beginning of the End? [2],” accessed Oct. 23, 2017.
2. Pfizer, “Pfizer Receives FDA Approval for Mylotarg (gemtuzumab ozogamicin) [3]…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
…ials (17–21) including antibody fragments, single-domain mAbs, Fc-fusions, vaccines, antibody-drug conjugates, nonantibody protein scaffolds, PEGylated proteins and peptides, and viral vectors.
…
Article
Single-Domain Antibodies for Brain Targeting
…ariants (diabodies, triabodies, minibodies, sdAbs) along with antibody-drug or antibody-nanoparticle conjugates are emerging as credible alternatives. Many of these products are under clinical invest…
Article
Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
Article
Evolving demands of process development services
And, more recently, there has been a high demand for the CDMOs that can handle oligos, peptides, and various complex conjugates. Novel conjugates involving combinations of oligos, peptides, high poten…
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Extractables Studies for Single‑Use Systems Used in ADC Manufacturing
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
Article
Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies?
Moscariello and Young (CMC Biologics): The major challenges…
Article
SEC in the Modern Downstream Purification Process
The separations of antibody-drug conjugates from the unbound payload molecule are also amenable to SEC. In these types of applications, the payload molecule (usually a cytotoxin) is added in a signifi…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…